Title: Autism-specific maternal autoantibodies recognize critical proteins in developing brain.
Authors: Braunschweig, D; Krakowiak, P; Duncanson, P; Boyce, R; Hansen, R L; Ashwood, P; Hertz-Picciotto, I; Pessah, I N; Van de Water, J
Published In Transl Psychiatry, (2013 Jul 09)
Abstract: Autism spectrum disorders (ASDs) are neurodevelopmental in origin, affecting an estimated 1 in 88 children in the United States. We previously described ASD-specific maternal autoantibodies that recognize fetal brain antigens. Herein, we demonstrate that lactate dehydrogenase A and B (LDH), cypin, stress-induced phosphoprotein 1 (STIP1), collapsin response mediator proteins 1 and 2 (CRMP1, CRMP2) and Y-box-binding protein to comprise the seven primary antigens of maternal autoantibody-related (MAR) autism. Exclusive reactivity to specific antigen combinations was noted in 23% of mothers of ASD children and only 1% of controls. ASD children from mothers with specific reactivity to LDH, STIP1 and CRMP1 and/or cypin (7% vs 0% in controls; P<0.0002; odds ratios of 24.2 (95% confidence interval: 1.45-405)) had elevated stereotypical behaviors compared with ASD children from mothers lacking these antibodies. We describe the first panel of clinically significant biomarkers with over 99% specificity for autism risk thereby advancing our understanding of the etiologic mechanisms and therapeutic possibilities for MAR autism.
PubMed ID: 23838888
MeSH Terms: Antibody Specificity/immunology; Autistic Disorder/immunology*; Autoantibodies/immunology*; Blotting, Western; Brain/growth & development*; Brain/immunology; Child; Electrophoresis, Gel, Two-Dimensional; Female; Guanine Deaminase/immunology; Humans; Intercellular Signaling Peptides and Proteins/immunology; Isoenzymes/immunology; L-Lactate Dehydrogenase/immunology; Maternal-Fetal Exchange/immunology; Nerve Tissue Proteins/immunology*; Pregnancy; Stereotyped Behavior; Y-Box-Binding Protein 1/immunology