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Title: Bisphenol A and chronic disease risk factors in US children.

Authors: Eng, Donna S; Lee, Joyce M; Gebremariam, Achamyeleh; Meeker, John D; Peterson, Karen; Padmanabhan, Vasantha

Published In Pediatrics, (2013 Sep)

Abstract: To evaluate the relationship between urinary bisphenol A (BPA) levels and measures of adiposity and chronic disease risk factors for a nationally representative US pediatric sample.We used the NHANES 2003-2010 to evaluate cross-sectional associations between urinary BPA and multiple measures of adiposity, cholesterol, insulin, and glucose for children aged 6 to 18 years, adjusting for relevant covariates (eg, demographics, urine creatinine, tobacco exposure, and soda consumption).We found a higher odds of obesity (BMI ≥95th percentile) with increasing quartiles of BPA for quartiles 2 vs 1 (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.17-2.60, P = .008), 3 vs 1 (OR 1.64, 95% CI 1.09-2.47, P = .02), and 4 vs 1 (OR 2.01, 95% CI 1.36-2.98, P = .001). We also found a higher odds of having an abnormal waist circumference-to-height ratio (quartiles 2 vs 1 [OR 1.37, 95% CI 0.98-1.93, P = .07], 3 vs 1 [OR 1.41, 95% CI 1.07-1.87, P = .02], and 4 vs 1 [OR 1.55, 95% CI 1.12-2.15, P = .01]). We did not find significant associations of BPA with any other chronic disease risk factors.Higher levels of urinary BPA were associated with a higher odds of obesity (BMI >95%) and abnormal waist circumference-to-height ratio. Longitudinal analyses are needed to elucidate temporal relationships between BPA exposure and the development of obesity and chronic disease risk factors in children.

PubMed ID: 23958765 Exiting the NIEHS site

MeSH Terms: Adolescent; Benzhydryl Compounds/adverse effects*; Benzhydryl Compounds/urine; Body Mass Index; Child; Chronic Disease/epidemiology*; Cross-Sectional Studies; Environmental Pollutants/adverse effects*; Environmental Pollutants/urine; Female; Humans; Male; Nutrition Surveys; Obesity/chemically induced*; Obesity/epidemiology*; Phenols/adverse effects*; Phenols/urine; Risk Factors; United States; Waist Circumference

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