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Publication Detail

Title: Maternal genotype and gestational diabetes.

Authors: Stuebe, Alison M; Wise, Alison; Nguyen, Thutrang; Herring, Amy; North, Kari E; Siega-Riz, Anna Maria

Published In Am J Perinatol, (2014 Jan)

Abstract: To determine whether genetic variants associated with glucose homeostasis are associated with gestational diabetes (GDM).We genotyped 899 self-identified Caucasian women and 386 self-identified African-American women in the Pregnancy, Infection and Nutrition (PIN) Studies cohorts for 38 single-nucleotide polymorphisms (SNPs) associated with type II diabetes (T2DM) and/or glucose homeostasis in European populations.GDM was diagnosed in 56 of 899 (6.2%) Caucasian and 24 of 386 (6.2%) African-American women. Among Caucasian women, GDM was associated with carriage of TCF7L2 rs7901695, MTNR1B rs10830963 and GCKR rs780094 alleles that are associated with T2DM and fasting glucose in nonpregnant populations. Among African-American participants, we found an increased risk among TSPAN8 rs7961581 C allele homozygotes and reduced risk among carriers of the JAZF1 rs864745 T allele.We found several SNPs that are associated with GDM risk in the PIN cohorts. Maternal genotyping may identify women at risk for impaired gestational glucose tolerance.

PubMed ID: 23456907 Exiting the NIEHS site

MeSH Terms: Adaptor Proteins, Signal Transducing/genetics; Adolescent; Adult; African Americans/genetics*; Blood Glucose/genetics; Diabetes Mellitus, Type 2/ethnology; Diabetes Mellitus, Type 2/genetics*; Diabetes, Gestational/ethnology; Diabetes, Gestational/genetics*; European Continental Ancestry Group/genetics*; Female; Heterozygote; Homeostasis/genetics; Homozygote; Humans; Neoplasm Proteins/genetics; North Carolina; Polymorphism, Single Nucleotide; Pregnancy; Receptor, Melatonin, MT2/genetics; Tetraspanins/genetics; Transcription Factor 7-Like 2 Protein/genetics; Young Adult

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