Title: NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet.
Authors: Dhar, Debanjan; Seki, Ekihiro; Karin, Michael
Published In Cell Metab, (2014 Jan 07)
Abstract: Although type 2 diabetes (T2D) is an established risk factor for hepatocellular carcinoma (HCC), the underlying mechanism that connects these two diseases is unknown. Gao et al. (2013) now suggest that nuclear receptor coactivator 5 (NCOA5) provides a genetic link between the two diseases through its effects on hepatic IL-6 expression.
PubMed ID: 24411937
MeSH Terms: Animals; Carcinoma, Hepatocellular/etiology*; Female; Glucose Intolerance/etiology*; Haploinsufficiency*; Humans; Liver Neoplasms/etiology*; Male; Nuclear Receptor Coactivators/genetics*