Title: The role of metal components in the cardiovascular effects of PM2.5.
Authors: Niu, Jingping; Liberda, Eric N; Qu, Song; Guo, Xinbiao; Li, Xiaomei; Zhang, Jingjing; Meng, Junliang; Yan, Bing; Li, Nairong; Zhong, Mianhua; Ito, Kazuhiko; Wildman, Rachel; Liu, Hong; Chen, Lung Chi; Qu, Qingshan
Published In PLoS One, (2013)
Abstract: Exposure to ambient fine particulate matter (PM2.5) increases risks for cardiovascular disorders (CVD). However, the mechanisms and components responsible for the effects are poorly understood. Based on our previous murine exposure studies, a translational pilot study was conducted in female residents of Jinchang and Zhangye, China, to test the hypothesis that specific chemical component of PM2.5 is responsible for PM2.5 associated CVD. Daily ambient and personal exposures to PM2.5 and 35 elements were measured in the two cities. A total of 60 healthy nonsmoking adult women residents were recruited for measurements of inflammation biomarkers. In addition, circulating endothelial progenitor cells (CEPCs) were also measured in 20 subjects. The ambient levels of PM2.5 were comparable between Jinchang and Zhangye (47.4 and 54.5 µg/m(3), respectively). However, the levels of nickel, copper, arsenic, and selenium in Jinchang were 82, 26, 12, and 6 fold higher than Zhangye, respectively. The levels of C-reactive protein (3.44 ± 3.46 vs. 1.55 ± 1.13), interleukin-6 (1.65 ± 1.17 vs. 1.09 ± 0.60), and vascular endothelial growth factor (117.6 ± 217.0 vs. 22.7 ± 21.3) were significantly higher in Jinchang. Furthermore, all phenotypes of CEPCs were significantly lower in subjects recruited from Jinchang than those from Zhangye. These results suggest that specific metals may be important components responsible for PM2.5-induced cardiovascular effects and that the reduced capacity of endothelial repair may play a critical role.
PubMed ID: 24386277
MeSH Terms: Aged; Biomarkers/metabolism; Blood Vessels/cytology; Blood Vessels/drug effects*; Blood Vessels/metabolism; Cell Count; Chemokine CXCL12/metabolism; Cities/statistics & numerical data; Endothelium/drug effects; Endothelium/metabolism; Female; Heart/drug effects*; Humans; Male; Metals/adverse effects*; Metals/analysis; Middle Aged; Myocardium/cytology; Myocardium/metabolism; Particle Size*; Particulate Matter/adverse effects*; Particulate Matter/chemistry*; Stem Cells/cytology; Stem Cells/drug effects; Vascular Endothelial Growth Factor A/blood; Vascular Endothelial Growth Factor A/metabolism