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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Gut microbiome phenotypes driven by host genetics affect arsenic metabolism.

Authors: Lu, Kun; Mahbub, Ridwan; Cable, Peter Hans; Ru, Hongyu; Parry, Nicola M A; Bodnar, Wanda M; Wishnok, John S; Styblo, Miroslav; Swenberg, James A; Fox, James G; Tannenbaum, Steven R

Published In Chem Res Toxicol, (2014 Feb 17)

Abstract: Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs raises the possibility that gut microbiome phenotypes affect the spectrum of metabolized arsenic species. However, it remains unclear how host genetics and the gut microbiome interact to affect the biotransformation of arsenic. Using an integrated approach combining 16S rRNA gene sequencing and HPLC-ICP-MS arsenic speciation, we demonstrate that IL-10 gene knockout leads to a significant taxonomic change of the gut microbiome, which in turn substantially affects arsenic metabolism.

PubMed ID: 24490651 Exiting the NIEHS site

MeSH Terms: Animals; Arsenic/pharmacokinetics*; Biotransformation; Chromatography, High Pressure Liquid; Environmental Pollutants/pharmacokinetics*; Gastrointestinal Tract/metabolism; Gastrointestinal Tract/microbiology*; Interleukin-10/genetics*; Mass Spectrometry; Mice; Mice, Knockout; Microbiota*; Phenotype; RNA, Ribosomal, 16S/genetics

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