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National Institute of Environmental Health Sciences

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Publication Detail

Title: Modulation of nuclear receptor function by cellular redox poise.

Authors: Carter, Eric L; Ragsdale, Stephen W

Published In J Inorg Biochem, (2014 Apr)

Abstract: Nuclear receptors (NRs) are ligand-responsive transcription factors involved in diverse cellular processes ranging from metabolism to circadian rhythms. This review focuses on NRs that contain redox-active thiol groups, a common feature within the superfamily. We will begin by describing NRs, how they regulate various cellular processes and how binding ligands, corepressors and/or coactivators modulate their activity. We will then describe the general area of redox regulation, especially as it pertains to thiol-disulfide interconversion and the cellular systems that respond to and govern this redox equilibrium. Lastly, we will discuss specific examples of NRs whose activities are regulated by redox-active thiols. Glucocorticoid, estrogen, and the heme-responsive receptor, Rev-erb, will be described in the most detail as they exhibit archetypal redox regulatory mechanisms.

PubMed ID: 24495544 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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