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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Organophosphorus flame retardants inhibit specific liver carboxylesterases and cause serum hypertriglyceridemia.

Authors: Morris, Patrick J; Medina-Cleghorn, Daniel; Heslin, Ann; King, Sarah M; Orr, Joseph; Mulvihill, Melinda M; Krauss, Ronald M; Nomura, Daniel K

Published In ACS Chem Biol, (2014 May 16)

Abstract: Humans are prevalently exposed to organophosphorus flame retardants (OPFRs) contained in consumer products and electronics, though their toxicological effects and mechanisms remain poorly understood. We show here that OPFRs inhibit specific liver carboxylesterases (Ces) and cause altered hepatic lipid metabolism. Ablation of the OPFR target Ces1g has been previously linked to dyslipidemia in mice. Consistent with OPFR inhibition of Ces1g, we also observe OPFR-induced serum hypertriglyceridemia in mice. Our findings suggest novel toxicities that may arise from OPFR exposure and highlight the utility of chemoproteomic and metabolomic platforms in the toxicological characterization of environmental chemicals.

PubMed ID: 24597639 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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