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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Are urinary PAHs biomarkers of controlled exposure to diesel exhaust?

Authors: Lu, Sixin S; Sobus, Jon R; Sallsten, Gerd; Albin, Maria; Pleil, Joachim D; Gudmundsson, Anders; Madden, Michael C; Strandberg, Bo; Wierzbicka, Aneta; Rappaport, Stephen M

Published In Biomarkers, (2014 Jun)

Abstract: Urinary polycyclic aromatic hydrocarbons (PAHs) were evaluated as possible biomarkers of exposure to diesel exhaust (DE) in two controlled-chamber studies. We report levels of 14 PAHs from 28 subjects in urine that were collected before, immediately after and the morning after exposure. Using linear mixed-effects models, we tested for effects of DE exposure and several covariates (time, age, gender and urinary creatinine) on urinary PAH levels. DE exposures did not significantly alter urinary PAH levels. We conclude that urinary PAHs are not promising biomarkers of short-term exposures to DE in the range of 106-276 µg/m(3).

PubMed ID: 24754404 Exiting the NIEHS site

MeSH Terms: Biomarkers/urine*; Creatinine/urine; Female; Humans; Male; Polycyclic Aromatic Hydrocarbons/urine*; Vehicle Emissions/toxicity*

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