Title: Plasma nitrite is an indicator of acute changes in ambient air pollutant concentrations.
Authors: Gandhi, Sampada K; Rich, David Q; Ohman-Strickland, Pamela A; Kipen, Howard M; Gow, Andrew
Published In Inhal Toxicol, (2014 Jun)
Abstract: Endothelial dysfunction has been suggested as a potential mechanism by which ambient air pollution may cause acute cardiovascular events. Recently, plasma nitrite has been developed as a marker of endothelial dysfunction.We examined the changes in plasma nitrite concentration associated with increases in ambient air pollutant concentrations in the previous 7 d.We linked up to three measurements of plasma nitrite concentrations obtained from 49 students to 24-h average concentrations of five criteria air pollutants [particle mass < 2.5 µm in aerodynamic diameter (PM(2.5)), carbon monoxide (CO), sulfur dioxide (SO₂), nitrogen dioxide (NO₂), and ozone (O₃)] measured at two monitoring sites closest to Rutgers University campus (6-15 miles) in New Jersey during the years 2006-2009. We examined the change in plasma nitrite associated with each interquartile-range (IQR) increase in pollutant concentration in the previous 24 h and six preceding 24- h periods, using linear mixed models.IQR increases in mean PM(2.5) (7.0 µg/m³) and CO (161.7 parts per billion) concentrations in the first 24 h before the plasma nitrite measurement were associated with increased plasma nitrite concentrations (PM(2.5): 15.5 nanomolar; 95% confidence interval (CI): 2.4, 28.5; CO: 15.6 nanomolar; 95% CI: 2.4, 28.9). Increased plasma nitrite associated with IQR increases in O₃ and SO₂ concentrations over longer lags were observed.Rapid increases in plasma nitrite following exposure to ambient air pollutants support the hypothesis that ambient air pollution is associated with inducible nitric oxide synthase-mediated systemic inflammation in humans.
PubMed ID: 24862977
MeSH Terms: Adolescent; Adult; Air Pollution/adverse effects*; Biological Markers/blood; Biological Markers/metabolism; Carbon Monoxide/analysis; Carbon Monoxide/toxicity*; Cross-Over Studies; Double-Blind Method; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Endothelium, Vascular/physiopathology; Environmental Monitoring; Female; Humans; Inhalation Exposure/adverse effects*; Male; Models, Biological*; New Jersey; Nitrites/blood*; Nitrites/metabolism; Ozone/analysis; Ozone/toxicity; Particulate Matter/analysis; Particulate Matter/toxicity*; Sulfur Dioxide/analysis; Sulfur Dioxide/toxicity; Systemic Vasculitis/blood; Systemic Vasculitis/chemically induced; Systemic Vasculitis/metabolism; Systemic Vasculitis/physiopathology; Toxicokinetics; Urban Health*; Young Adult