Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Success of the two-dose methotrexate protocol for treatment of ectopic pregnancy in women with a history of prior ectopic pregnancy.

Authors: McLaren, Janet F; Barnhart, Kurt T; Sammel, Mary D; Appleby, Dina H; Butts, Samantha F

Published In J Reprod Med, (2014 Jul-Aug)

Abstract: Women with prior ectopic pregnancy (EP) have an increased failure rate when treated with single-dose methotrexate (MTX) for subsequent EP. We sought to determine whether previous EP remained a risk factor for failure when using the two-dose MTX protocol.Retrospective cohort study of women managed with two-dose MTX. Risk factors for MTX failure were evaluated in univariable analysis and multivariable regression modeling.A total of 234 women with EP between 1999 and 2009 were studied. Of those, 37 (15.8%) had a prior EP. In univariable analysis, prior EP was associated with a greater than twofold increased risk of MTX failure (RR 2.67, 95% CI 1.20-3.77). Higher hCG levels and ultrasound visualization of EP also increased the risk of MTX failure. In multivariable analysis hCG level remained associated with MTX failure, while prior EP did not (adjusted RR 0.97, 95% CI 0.33-2.82).Prior EP is not independently associated with MTX failure in women receiving two-dose MTX therapy after controlling for known risk factors.

PubMed ID: 25098028 Exiting the NIEHS site

MeSH Terms: Abortifacient Agents, Nonsteroidal/administration & dosage*; Adult; Chorionic Gonadotropin/analysis; Cohort Studies; Dose-Response Relationship, Drug; Female; Humans; Methotrexate/administration & dosage*; Multivariate Analysis; Pregnancy; Pregnancy, Ectopic/diagnostic imaging; Pregnancy, Ectopic/drug therapy*; Recurrence; Retrospective Studies; Risk Assessment; Risk Factors; Treatment Failure; Ultrasonography

to Top