Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: MicroRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma.

Authors: Poenitzsch Strong, Ashley M; Setaluri, Vijayasaradhi; Spiegelman, Vladimir S

Published In Arch Biochem Biophys, (2014 Dec 1)

Abstract: microRNA (miRNA)-dependent regulation of gene expression is increasingly linked to development and progression of melanoma. In this study we evaluated the functions of miR-340 in human melanoma cells. Here, we show that miR-340 inhibits the tumorigenic phenotype of melanoma cells. We also found that miR-340 regulates RAS-RAF-Mitogen Activated Protein Kinase (MAPK) signaling by modulating the expression of multiple components of this pathway. Given the importance of MAPK signaling in melanoma, these results provide further insight into the pathogenesis of melanoma.

PubMed ID: 25043973 Exiting the NIEHS site

MeSH Terms: Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; MAP Kinase Signaling System/genetics*; Melanoma/etiology; Melanoma/genetics*; Melanoma/metabolism*; MicroRNAs/genetics*; MicroRNAs/metabolism*; Mutation; Phenotype; Signal Transduction/genetics; raf Kinases/metabolism*; ras Proteins/metabolism*

Back
to Top