Title: Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.
Authors: Wang, Hansong; Burnett, Terrilea; Kono, Suminori; Haiman, Christopher A; Iwasaki, Motoki; Wilkens, Lynne R; Loo, Lenora W M; Van Den Berg, David; Kolonel, Laurence N; Henderson, Brian E; Keku, Temitope O; Sandler, Robert S; Signorello, Lisa B; Blot, William J; Newcomb, Polly A; Pande, Mala; Amos, Christopher I; West, Dee W; Bézieau, Stéphane; Berndt, Sonja I; Zanke, Brent W; Hsu, Li; Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO); Lindor, Noralane M; Haile, Robert W; Hopper, John L; Jenkins, Mark A; Gallinger, Steven; Casey, Graham; Colon Cancer Family Registry (CCFR); Stenzel, Stephanie L; Schumacher, Fredrick R; Peters, Ulrike; Gruber, Stephen B; Colorectal Transdisciplinary Study (CORECT); Tsugane, Shoichiro; Stram, Daniel O; Le Marchand, Loïc
Published In Nat Commun, (2014 Aug 08)
Abstract: The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 × 10(-9)), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.
PubMed ID: 25105248
MeSH Terms: African Americans/genetics; Alleles; Asian Continental Ancestry Group/genetics; Case-Control Studies; Chromosome Mapping; Colorectal Neoplasms/ethnology*; Colorectal Neoplasms/genetics*; European Continental Ancestry Group/genetics; Genetic Loci; Genetic Predisposition to Disease*; Genome-Wide Association Study*; Genotype; Humans; Japan; Polymorphism, Single Nucleotide; Qb-SNARE Proteins/genetics*; United States