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National Institute of Environmental Health Sciences

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Publication Detail

Title: Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms.

Authors: Medina-Cleghorn, Daniel; Nomura, Daniel K

Published In Chem Biol, (2014 Sep 18)

Abstract: Genome sequencing efforts have revealed a strikingly large number of uncharacterized genes, including poorly or uncharacterized metabolic enzymes, metabolites, and metabolic networks that operate in normal physiology, and those enzymes and pathways that may be rewired under pathological conditions. Although deciphering the functions of the uncharacterized metabolic genome is a challenging prospect, it also presents an opportunity for identifying novel metabolic nodes that may be important in disease therapy. In this review, we will discuss the chemoproteomic and metabolomic platforms used in identifying, characterizing, and targeting nodal metabolic pathways important in physiology and disease, describing an integrated workflow for functional mapping of metabolic enzymes.

PubMed ID: 25237861 Exiting the NIEHS site

MeSH Terms: Enzymes/chemistry; Enzymes/metabolism; Epigenesis, Genetic; Humans; Metabolic Networks and Pathways; Metabolomics*; Molecular Probes/chemistry; Molecular Probes/metabolism; Protein Processing, Post-Translational; Proteomics*

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