Title: In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort.
Authors: Nadeau, Kari C; Li, Zhigang; Farzan, Shohreh; Koestler, Devin; Robbins, David; Fei, Dennis Liang; Malipatlolla, Meena; Maecker, Holden; Enelow, Richard; Korrick, Susan; Karagas, Margaret R
Published In Clin Immunol, (2014 Dec)
Abstract: Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4+/CD8+ T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10 μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA+ CD4+ cord blood CD69+ T cell counts (N=116, p=0.04) and positively associated with CD45RA+ CD69- CD294+ cell counts (p=0.01). In placental samples (N=70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β (p=0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation.
PubMed ID: 25229165
MeSH Terms: Adult; Arsenic/adverse effects*; Female; Fetal Blood/cytology; Gene Expression; Humans; Immune System/drug effects*; Immune System/physiology*; Immunophenotyping; Infant, Newborn; Interleukin-1beta/genetics; Interleukin-1beta/metabolism; Lymphocyte Activation/immunology; Male; Maternal Exposure/adverse effects*; New Hampshire; Phenotype; Placenta/immunology; Placenta/metabolism; Pregnancy; Prenatal Exposure Delayed Effects/immunology*; Risk Factors; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/metabolism