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Title: Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus.

Authors: Lin, Zhenjian; Koch, Michael; Abdel Aziz, May Hamdy; Galindo-Murillo, Rodrigo; Tianero, Ma Diarey; Cheatham, Thomas E; Barrows, Louis R; Reilly, Chris A; Schmidt, Eric W

Published In Org Lett, (2014 Sep 19)

Abstract: A racemic, prenylated polyketide dimer, oxazinin A (1), was isolated from a novel filamentous fungus in the class Eurotiomycetes, and its structure was elucidated spectroscopically. The pentacyclic structure of oxazinin A (1) is a unique combination of benzoxazine, isoquinoline, and a pyran ring. Oxazinin A (1) exhibited antimycobacterial activity and modestly antagonized transient receptor potential (TRP) channels.

PubMed ID: 25188821 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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