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Title: Associations of work hours, job strain, and occupation with endothelial function: the Multi-Ethnic Study of Atherosclerosis (MESA).

Authors: Charles, Luenda E; Fekedulegn, Desta; Landsbergis, Paul; Burchfiel, Cecil M; Baron, Sherry; Kaufman, Joel D; Stukovsky, Karen Hinckley; Fujishiro, Kaori; Foy, Capri G; Andrew, Michael E; Diez Roux, Ana V

Published In J Occup Environ Med, (2014 Nov)

Abstract: To investigate associations of work hours, job control, job demands, job strain, and occupational category with brachial artery flow-mediated dilation (FMD) in 1499 Multi-Ethnic Study of Atherosclerosis participants.Flow-mediated dilation was obtained using high-resolution ultrasound. Mean values of FMD were examined across categories of occupation, work hours, and the other exposures using regression analyses.Occupational category was significantly associated with FMD overall, with blue-collar workers showing the lowest mean values-management/professional = 4.97 ± 0.22%; sales/office = 5.19 ± 0.28%; services = 4.73 ± 0.29%; and blue-collar workers = 4.01 ± 0.26% (adjusted P < 0.001). There was evidence of effect modification by sex (interaction P = 0.031)-significant associations were observed among women (adjusted P = 0.002) and nearly significant results among men (adjusted P = 0.087). Other exposures were not significantly associated with FMD.Differences in endothelial function may account for some of the variation in cardiovascular disease across occupational groups.

PubMed ID: 25376409 Exiting the NIEHS site

MeSH Terms: African Americans; Asian Americans; Atherosclerosis/ethnology; Atherosclerosis/physiopathology*; Brachial Artery/physiology*; Endothelium, Vascular/physiopathology*; European Continental Ancestry Group; Female; Hispanic Americans; Humans; Male; Middle Aged; Occupations; Professional Autonomy; Regional Blood Flow; Sex Factors; Stress, Psychological/physiopathology*; Surveys and Questionnaires; Vasodilation*; Work Schedule Tolerance/physiology; Workload

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