Title: The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study.

Authors: Sharp, Madeleine E; Caccappolo, Elise; Mejia-Santana, Helen; Tang, Ming-X; Rosado, Llency; Orbe Reilly, Martha; Ruiz, Diana; Louis, Elan D; Comella, Cynthia; Nance, Martha; Bressman, Susan; Scott, William K; Tanner, Caroline; Waters, Cheryl; Fahn, Stanley; Cote, Lucien; Ford, Blair; Rezak, Michael; Novak, Kevin; Friedman, Joseph H; Pfeiffer, Ronald; Payami, Haydeh; Molho, Eric; Factor, Stuart A; Nutt, John; Serrano, Carmen; Arroyo, Maritza; Pauciulo, Michael W; Nichols, William C; Clark, Lorraine N; Alcalay, Roy N; Marder, Karen S

Published In Mov Disord, (2015 Feb)

Abstract: BACKGROUND: Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS). METHODS: The Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early-onset PD and 257 asymptomatic first-degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers. RESULTS: Among patients, carriers scored lower than noncarriers in adjusted models (one-mutation: 13.9 point difference, P = 0.03; two-mutation: 24.1, P = 0.001), where lower scores indicate less OCS. Among asymptomatic relatives, a trend toward the opposite was seen: mutation carriers scored higher than noncarriers (one mutation, P = 0.05; two mutations, P = 0.13). CONCLUSIONS: First, a significant association was found between PARKIN mutation status and obsessive-compulsive symptom level in both PD and asymptomatic patients, suggesting that OCS might represent an early non-motor dopamine-dependent feature. Second, irrespective of disease status, heterozygotes were significantly different from noncarriers, suggesting that PARKIN heterozygosity may contribute to phenotype. © 2014 International Parkinson and Movement Disorder Society.

PubMed ID: 25393808

MeSH Terms: Adult; Age of Onset; Aged; Female; Genetic Predisposition to Disease*; Genetic Testing; Genotype; Heterozygote; Humans; Male; Middle Aged; Mutation/genetics*; Obsessive-Compulsive Disorder/etiology; Obsessive-Compulsive Disorder/genetics*; Parkinson Disease/complications; Parkinson Disease/genetics*; Ubiquitin-Protein Ligases/genetics*