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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Impact of respiratory illness on expiratory flow rates in normal, asthmatic, and allergic children.

Authors: Rappaport, Edward B; Gilliland, Frank D; Linn, William S; Gauderman, W James

Published In Pediatr Pulmonol, (2002 Aug)

Abstract: We examined the effects of current respiratory illness (RI) on pulmonary function (PF) in 1,103 subjects who underwent spirometry at schools twice within a 4-month period. Before spirometry, subjects were asked if they had a "cold or other chest illness" during the previous month, and if so, whether they had fully recovered. Those who had not recovered were considered to have an RI. We found that children without RI at their first PF test who reported RI on retest had significantly lower forced expiratory volume in 1 sec (FEV(1)) (-0.8%), peak expiratory flow rate (PEFR) (-2.2%), forced expiratory flow between 25-75% of vital capacity (FEF(25-75)) (-3.5%), and forced expiratory flow at 75% of vital capacity (FEF(75)) (-5.1%) than those without RI on both test and retest. Restriction of subjects to those without a history of doctor-diagnosed asthma did not appreciably change these findings. Children with hay fever had significantly larger RI-associated decreases for FEV(1), FEF(25-75), and FEF(75), but not PEFR, than those without hay fever. Among asthmatic subjects, those with active asthma had larger RI-associated decreases in FEF(25-75) and FEF(75), but not PEFR, than those without asthma. There was limited evidence that small airway losses were greater in children less than 12.5 years old. We conclude that RI in children who are well enough to attend school may reduce expiratory flow rates. These effects are greater for children with active asthma or hay fever than in those without, and may be inversely related to age.

PubMed ID: 12112777 Exiting the NIEHS site

MeSH Terms: Adolescent; Adult; Age Factors; Asthma/complications*; Asthma/physiopathology*; Child; Cohort Studies; Forced Expiratory Flow Rates/physiology*; Health Status; Humans; Reference Values; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Respiration Disorders/complications*; Respiration Disorders/physiopathology*; Rhinitis, Allergic, Seasonal/complications*; Rhinitis, Allergic, Seasonal/physiopathology*; Sex Factors; Spirometry

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