Skip Navigation

Publication Detail

Title: The mammary gland is a sensitive pubertal target in CD-1 and C57Bl/6 mice following perinatal perfluorooctanoic acid (PFOA) exposure.

Authors: Tucker, Deirdre K; Macon, Madisa B; Strynar, Mark J; Dagnino, Sonia; Andersen, Erik; Fenton, Suzanne E

Published In Reprod Toxicol, (2015 Jul)

Abstract: Perfluorooctanoic acid (PFOA) is a developmental toxicant in mice, with varied strain outcomes depending on dose and period of exposure. The impact of PFOA on female mouse pubertal development at low doses (≤1mg/kg) has yet to be determined. Therefore, female offspring from CD-1 and C57Bl/6 dams exposed to PFOA, creating serum concentrations similar to humans, were examined for pubertal onset, including mammary gland development. Pups demonstrated a shorter PFOA elimination half-life than that reported for adult mice. Prenatal exposure to PFOA caused significant mammary developmental delays in female offspring in both strains. Delays started during puberty and persisted into young adulthood; severity was dose-dependent. Also an evaluation of female serum hormone levels and pubertal timing onset revealed no effects of PFOA compared to controls in either strain. These data suggest that the mammary gland is more sensitive to early low level PFOA exposures compared to other pubertal endpoints, regardless of strain.

PubMed ID: 25499722 Exiting the NIEHS site

MeSH Terms: Age Factors; Animals; Body Burden; Caprylates/toxicity*; Dose-Response Relationship, Drug; Environmental Pollutants/toxicity*; Female; Fluorocarbons/toxicity*; Gestational Age; Liver/drug effects; Liver/pathology; Mammary Glands, Animal/drug effects*; Mammary Glands, Animal/growth & development; Maternal Exposure/adverse effects*; Mice, Inbred C57BL; Pregnancy; Prenatal Exposure Delayed Effects*; Risk Assessment; Risk Factors; Sexual Development/drug effects

Back
to Top