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Publication Detail

Title: Modeling prolactin actions in breast cancer in vivo: insights from the NRL-PRL mouse.

Authors: O'Leary, Kathleen A; Shea, Michael P; Schuler, Linda A

Published In Adv Exp Med Biol, (2015)

Abstract: Elevated exposure to prolactin (PRL) is epidemiologically associated with an increased risk of aggressive ER+ breast cancer. To understand the underlying mechanisms and crosstalk with other oncogenic factors, we developed the NRL-PRL mouse. In this model, mammary expression of a rat prolactin transgene raises local exposure to PRL without altering estrous cycling. Nulliparous females develop metastatic, histotypically diverse mammary carcinomas independent from ovarian steroids, and most are ER+. These characteristics resemble the human clinical disease, facilitating study of tumorigenesis, and identification of novel preventive and therapeutic approaches.

PubMed ID: 25472540 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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