Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.

Authors: Maazi, Hadi; Patel, Nisheel; Sankaranarayanan, Ishwarya; Suzuki, Yuzo; Rigas, Diamanda; Soroosh, Pejman; Freeman, Gordon J; Sharpe, Arlene H; Akbari, Omid

Published In Immunity, (2015 Mar 17)

Abstract: Allergic asthma is caused by Th2-cell-type cytokines in response to allergen exposure. Type 2 innate lymphoid cells (ILC2s) are a newly identified subset of immune cells that, along with Th2 cells, contribute to the pathogenesis of asthma by producing copious amounts of IL-5 and IL-13, which cause eosinophilia and airway hyperreactivity (AHR), a cardinal feature of asthma. ILC2s express ICOS, a T cell costimulatory molecule with a currently unknown function. Here we showed that a lack of ICOS on murine ILC2s and blocking the ICOS:ICOS-ligand interaction in human ILC2s reduced AHR and lung inflammation. ILC2s expressed both ICOS and ICOS-ligand, and the ICOS:ICOS-ligand interaction promoted cytokine production and survival in ILC2s through STAT5 signaling. Thus, ICOS:ICOS-ligand signaling pathway is critically involved in ILC2 function and homeostasis.

PubMed ID: 25769613 Exiting the NIEHS site

MeSH Terms: Animals; Asthma/genetics; Asthma/immunology*; Asthma/pathology; Female; Gene Expression Regulation; Homeostasis; Humans; Immunity, Innate; Inducible T-Cell Co-Stimulator Ligand/genetics; Inducible T-Cell Co-Stimulator Ligand/immunology*; Inducible T-Cell Co-Stimulator Protein/genetics; Inducible T-Cell Co-Stimulator Protein/immunology*; Interleukin-13/genetics; Interleukin-13/immunology; Interleukin-2/genetics; Interleukin-2/immunology; Interleukin-33; Interleukin-5/genetics; Interleukin-5/immunology; Interleukins/genetics; Interleukins/immunology; Lymphocytes/immunology*; Lymphocytes/pathology; Mice, Transgenic; Respiratory System/immunology; Respiratory System/pathology; STAT5 Transcription Factor/genetics; STAT5 Transcription Factor/immunology; Signal Transduction

Back
to Top