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Title: Molecular mechanisms of acrolein toxicity: relevance to human disease.

Authors: Moghe, Akshata; Ghare, Smita; Lamoreau, Bryan; Mohammad, Mohammad; Barve, Shirish; McClain, Craig; Joshi-Barve, Swati

Published In Toxicol Sci, (2015 Feb)

Abstract: Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant and its potential as a serious environmental health threat is beginning to be recognized. Humans are exposed to acrolein per oral (food and water), respiratory (cigarette smoke, automobile exhaust, and biocide use) and dermal routes, in addition to endogenous generation (metabolism and lipid peroxidation). Acrolein has been suggested to play a role in several disease states including spinal cord injury, multiple sclerosis, Alzheimer's disease, cardiovascular disease, diabetes mellitus, and neuro-, hepato-, and nephro-toxicity. On the cellular level, acrolein exposure has diverse toxic effects, including DNA and protein adduction, oxidative stress, mitochondrial disruption, membrane damage, endoplasmic reticulum stress, and immune dysfunction. This review addresses our current understanding of each pathogenic mechanism of acrolein toxicity, with emphasis on the known and anticipated contribution to clinical disease, and potential therapies.

PubMed ID: 25628402 Exiting the NIEHS site

MeSH Terms: Acrolein/metabolism; Acrolein/toxicity*; Antioxidants/metabolism; Apoptosis/drug effects; Cytokines/immunology; DNA Adducts/metabolism; Disease/etiology*; Environmental Exposure/adverse effects*; Environmental Pollutants/metabolism; Environmental Pollutants/toxicity*; Humans; Mitochondria/drug effects; Mitochondria/metabolism; Oxidative Stress/drug effects*; Signal Transduction/drug effects

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