Title: Manganese-induced Neurotoxicity: From C. elegans to Humans.
Authors: Chen, Pan; Chakraborty, Sudipta; Peres, Tanara V; Bowman, Aaron B; Aschner, Michael
Published In Toxicol Res (Camb), (2015 Mar 01)
Abstract: Manganese (Mn) is one of the most abundant metals on the earth. It is required for normal cellular activities, but overexposure leads to toxicity. Neurons are more susceptible to Mn-induced toxicity than other cells, and accumulation of Mn in the brain results in Manganism that presents with Parkinson's disease (PD)-like symptoms. In the last decade, a number of Mn transporters have been identified, which improves our understanding of Mn transport in and out of cells. However, the mechanism of Mn-induced neurotoxicity is only partially uncovered, with further research needed to explore the whole picture of Mn-induced toxicity. In this review, we will address recent progress in Mn-induced neurotoxicity from C. elegans to humans, and explore future directions that will help understand the mechanisms of its neurotoxicity.
PubMed ID: 25893090
MeSH Terms: No MeSH terms associated with this publication