Title: Serial Free Bisphenol A and Bisphenol A Glucuronide Concentrations in Neonates.

Authors: Nachman, Rebecca M; Fox, Stephen D; Golden, W Christopher; Sibinga, Erica; Groopman, John D; Lees, Peter S J

Published In J Pediatr, (2015 Jul)

Abstract: OBJECTIVE: To determine the balance of metabolism of free bisphenol A (BPA) to the inactive conjugate, BPA glucuronide (BPAG), in neonates. STUDY DESIGN: Free BPA and BPAG concentrations were measured in 78 urine samples collected between December 2012 and August 2013 from a cohort of 44 healthy full term (≥ 37 weeks' gestation) neonates at 2 intervals (3-6 days and 7-27 days of age). A questionnaire was administered at the time of sample collection. Neonates recruited into the study were born in an urban, tertiary care hospital. RESULTS: Only BPAG was detected in the urine samples; concentrations ranged from <0.1 μg/L to 11.21 μg/L (median: 0.27 μg/L). Free BPA concentrations were below the limit of quantification of 0.1 μg/L. Age, but not sex or type of diet, was significantly associated with urinary BPAG concentration (P = .002). CONCLUSIONS: Our results illustrate widespread BPA exposure in healthy full-term neonates and efficient conjugation of BPA to its readily excretable and biologically inactive form (BPAG) as early as 3 days of age. Factors other than type of diet may be important contributors to BPA exposure in neonates.

PubMed ID: 25921439

MeSH Terms: Age Factors; Benzhydryl Compounds/urine*; Breast Feeding; Female; Glucuronides/urine*; Humans; Infant Formula; Infant, Newborn; Male; Phenols/urine*; Sex Factors