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Title: Environmental Influences on Genomic Imprinting.

Authors: Kappil, Maya; Lambertini, Luca; Chen, Jia

Published In Curr Environ Health Rep, (2015 Jun)

Abstract: Genomic imprinting refers to the epigenetic mechanism that results in the mono-allelic expression of a subset of genes in a parent-of-origin manner. These haploid genes are highly active in the placenta and are functionally implicated in the appropriate development of the fetus. Furthermore, the epigenetic marks regulating imprinted expression patterns are established early in development. These characteristics make genomic imprinting a potentially useful biomarker for environmental insults, especially during the in utero or early development stages, and for health outcomes later in life. Herein, we critically review the current literature regarding environmental influences on imprinted genes and summarize findings that suggest that imprinted loci are sensitive to known teratogenic agents, such as alcohol and tobacco, as well as less established factors with the potential to manipulate the in utero environment, including assisted reproductive technology. Finally, we discuss the potential of genomic imprinting to serve as an environmental sensor during early development.

PubMed ID: 26029493 Exiting the NIEHS site

MeSH Terms: DNA Methylation; Environmental Exposure/adverse effects*; Epigenesis, Genetic; Female; Fetal Development/genetics; Genomic Imprinting*; Humans; Pregnancy

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