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Publication Detail

Title: Maternal fish consumption during pregnancy and risk of early childhood asthma.

Authors: Salam, Muhammad T; Li, Yu-Fen; Langholz, Bryan; Gilliland, Frank D

Published In J Asthma, (2005 Jul-Aug)

Abstract: Maternal fish consumption during pregnancy may affect children's asthma risk by modulating early-life immune development. Type of fish intake may be important because of differences in fatty acid content. To test this hypothesis, we conducted a nested case-control study, selecting subjects from the Children's Health Study, a population-based study of school-aged children in southern California. Cases had physician-diagnosed asthma and controls were asthma-free by age 5 years. Mothers or guardians provided information on fish consumption during pregnancy in telephone interviews. We computed odds ratio (OR) and 95% confidence interval (CI) by using conditional logistic regression models that accounted for the sampling. In children born to mothers with a history of asthma, the OR of asthma was 0.20 (95% CI = 0.06-0.65) when mothers ate oily fish at least monthly during pregnancy compared with no consumption (p(trend) = 0.006). Maternal oily fish consumption during pregnancy did not benefit children of non-asthmatic mothers. In contrast, fish stick (a source of trans-fats) consumption during pregnancy increased asthma risk in children (OR = 2.04; 95% CI = 1.18-3.51). Our results suggest that maternal oily fish intake during pregnancy may protect offspring from asthma; however, eating fish sticks during pregnancy may increase asthma risk in children.

PubMed ID: 16293548 Exiting the NIEHS site

MeSH Terms: Animals; Asthma/etiology*; Asthma/prevention & control*; Case-Control Studies; Child, Preschool; Confidence Intervals; Diet*; Female; Fish Oils/administration & dosage; Fishes*; Humans; Interviews; Odds Ratio; Pregnancy*; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Risk Assessment; Trans Fatty Acids/administration & dosage

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