Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules.

Authors: Chen, Yu; Santella, Regina M; Kibriya, Muhammad G; Wang, Qiao; Kappil, Maya; Verret, Wendy J; Graziano, Joseph H; Ahsan, Habibul

Published In Environ Health Perspect, (2007 Oct)

Abstract: Epidemiologic studies of cardiovascular disease risk factors and appropriate biomarkers in populations exposed to a wide range of arsenic levels are a public health research priority.We investigated the relationship between inorganic arsenic exposure from drinking water and plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1), both markers of endothelial dysfunction and vascular inflammation, in an arsenic-exposed population in Araihazar, Bangladesh.The study participants included 115 individuals with arsenic-related skin lesions participating in a 2 x 2 randomized, placebo-controlled, double-blind trial of vitamin E and selenium supplementation. Arsenic exposure status and plasma levels of sICAM-1 and sVCAM-1 were assessed at baseline and after 6 months of follow-up.Baseline well arsenic, a long-term measure of arsenic exposure, was positively associated with baseline levels of both sICAM-1 and sVCAM-1 and with changes in the two markers over time. At baseline, for every 1-mug/L increase in well arsenic there was an increase of 0.10 ng/mL [95% confidence interval (CI), 0.00-0.20] and 0.33 ng/mL (95% CI, 0.15-0.51) in plasma sICAM-1 and sVCAM-1, respectively. Every 1-microg/L increase in well arsenic was associated with a rise of 0.11 ng/mL (95% CI, 0.01-0.22) and 0.17 ng/mL (95% CI, 0.00-0.35) in sICAM-1 and sVCAM-1 from baseline to follow-up, respectively, in spite of recent changes in urinary arsenic as well as vitamin E and selenium supplementation during the study period.The findings indicate an effect of chronic arsenic exposure from drinking water on vascular inflammation that persists over time and also suggest a potential mechanism underlying the association between arsenic exposure and cardiovascular disease.

PubMed ID: 17938729 Exiting the NIEHS site

MeSH Terms: Adult; Arsenic Poisoning/epidemiology; Arsenic Poisoning/immunology*; Arsenic/blood*; Arsenic/urine; Bangladesh/epidemiology; Biomarkers/blood; Cardiovascular Diseases/physiopathology; Environmental Exposure*; Epidemiologic Studies; Female; Humans; Inflammation; Intercellular Adhesion Molecule-1/blood*; Male; Middle Aged; Prospective Studies; Vascular Cell Adhesion Molecule-1/blood*; Water Pollutants, Chemical/adverse effects*; Water Supply

to Top