Title: Dietary soy and increased risk of bladder cancer: a prospective cohort study of men in Shanghai, China.
Authors: Sun, Can-Lan; Yuan, Jian-Min; Wang, Xue-Li; Gao, Yu-Tang; Ross, Ronald K; Yu, Mimi C
Published In Int J Cancer, (2004 Nov 1)
Abstract: To verify our previous finding of a positive association between dietary soy and bladder cancer risk, we examined the association in a second, geographically distinct prospective cohort of Chinese subjects, the Shanghai Cohort Study. Briefly, 18,244 men aged 45-64 years were recruited between January 1986 and September 1989. As of December 31, 2002, 61 incident bladder cancer cases were identified. Information on soy consumption was obtained through in-person interviews at baseline using a food frequency questionnaire. Cox proportional hazard regression methods were used to estimate relative risks (RR) and their corresponding 95% confidence intervals (CI), with adjustment for age (years) at baseline interview, level of education and other potential confounders. Compared to men consuming soy less than once a week, the RR (95% CI) for those who consumed soy 1-<3 times per week, 3-<7 times a week and daily were 2.05 (0.80-5.29), 2.45 (0.89-6.76) and 4.61 (1.57-13.51), respectively (p for trend = 0.004), after adjustment for age, cigarette smoking and level of education. The soy-bladder cancer risk associations in smokers and non-smokers were comparable. The soy-bladder cancer relationship became stronger when the analysis was restricted to subjects with 2 or more years of follow-up.
PubMed ID: 15352046
MeSH Terms: China/epidemiology; Diet*; Humans; Incidence; Male; Middle Aged; Prospective Studies; Risk Factors; Sex Factors; Soy Foods*; Urinary Bladder Neoplasms/epidemiology; Urinary Bladder Neoplasms/etiology*