Title: Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation.

Authors: Hosoki, Koa; Itazawa, Toshiko; Boldogh, Istvan; Sur, Sanjiv

Published In Curr Opin Allergy Clin Immunol, (2016 Feb)

Abstract: To discuss the presence and role of neutrophils in asthma and allergic diseases, and outline the importance of pollen and cat dander-induced innate neutrophil recruitment in induction of allergic sensitization and allergic inflammation.Uncontrolled asthma is associated with elevated numbers of neutrophils, and levels of neutrophil-attracting chemokine IL-8 and IL-17 in bronchoalveolar lavage fluids. These parameters negatively correlate with lung function. Pollen allergens and cat dander recruit neutrophils to the airways in a toll-like receptor 4, myeloid differentiation protein-2, and chemokine (C-X-C motif) receptor (CXCR) 2-dependent manner. Repeated recruitment of activated neutrophils by these allergens facilitates allergic sensitization and airway inflammation. Inhibition of neutrophil recruitment with CXCR2 inhibitor, disruption of toll-like receptor 4, or small interfering RNA against myeloid differentiation protein-2 also inhibits allergic inflammation. The molecular mechanisms by which innately recruited neutrophils contribute to shifting the airway inflammatory response induced by allergens from neutrophilic to an eosinophilic-allergic is an area of active research.Recent studies have revealed that neutrophil recruitment is important in the development of allergic sensitization and inflammation. Inhibition of neutrophils recruitment may be a strategy to control allergic inflammation.

PubMed ID: 26694038

MeSH Terms: Allergens/immunology*; Animals; Asthma/immunology*; Asthma/pathology; Cats; Humans; Immunity, Innate*; Interleukin-17/immunology; Interleukin-8/immunology; Lymphocyte Antigen 96/immunology; Neutrophil Infiltration*; Neutrophils/immunology*; Neutrophils/pathology; Receptors, Interleukin-8B/immunology; Toll-Like Receptor 4/immunology