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Title: Hydroxylated polychlorinated biphenyls in human sera from adolescents and their mothers living in two U.S. Midwestern communities.

Authors: Koh, Wen Xin; Hornbuckle, Keri C; Marek, Rachel F; Wang, Kai; Thorne, Peter S

Published In Chemosphere, (2016 Mar)

Abstract: Hydroxylated polychlorinated biphenyls (OH-PCBs) have been detected in human specimens and some are suspected as being more toxic than their parent compounds. We compared 58 OH-PCB congeners (in 51 chromatographic peaks) in serum samples from participants in the AESOP Study, a longitudinal cohort study of adolescents and their mothers living in urban and rural areas in the United States. We hypothesized that adolescents would have lower levels of OH-PCBs than their mothers and that serum concentration of OH-PCBs would be stable over a 3-year period. We found statistically significant differences in total OH-PCBs between age groups in both East Chicago (p = 0.001) and Columbus Junction (p < 0.001), with adolescents having lower concentrations than their mothers. We observed that lower-chlorinated OH-PCBs were rarely detected, suggesting that they are not retained in serum and/or rapidly biotransformed into other forms. Twelve OH-PCBs, including several that are rarely reported (4,4'-diOH-PCB 202, 4'-OH-PCB 208, and 4-OH-PCB 163) were detected in over 60% of participants. Lastly, from repeated measures within subject serum for three OH-PCBs, concentrations of 4-OH-PCB 107 and 4-OH-PCB 187 changed significantly over three years of the study.

PubMed ID: 26774304 Exiting the NIEHS site

MeSH Terms: Adolescent; Adult; Cohort Studies; Environmental Exposure*; Environmental Pollutants/blood*; Female; Humans; Hydroxylation; Indiana; Iowa; Male; Middle Aged; Mothers; Polychlorinated Biphenyls/blood*; Rural Population; Urban Population

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