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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Relating Phthalate and BPA Exposure to Metabolism in Peripubescence: The Role of Exposure Timing, Sex, and Puberty.

Authors: Watkins, Deborah J; Peterson, Karen E; Ferguson, Kelly K; Mercado-García, Adriana; Tamayo y Ortiz, Marcela; Cantoral, Alejandra; Meeker, John D; Téllez-Rojo, Martha Maria

Published In J Clin Endocrinol Metab, (2016 Jan)

Abstract: Exposure to endocrine-disrupting chemicals during development may play a role in the increasing prevalence of metabolic syndrome and type 2 diabetes among children and adolescents by interfering with metabolic homeostasis.To explore associations between in utero and peripubertal urinary phthalate metabolite and bisphenol A (BPA) concentrations and markers of peripubertal metabolic homeostasis.Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT): a longitudinal cohort study of pregnant women in Mexico City and their offspring.Public maternity hospitals in Mexico City.Women recruited during pregnancy; offspring recruited for follow-up at age 8-14 years (n = 250).None.Fasting serum c-peptide, IGF-1, leptin, and glucose concentrations among children at follow-up; calculated measures of insulin secretion and insulin resistance.Phthalate metabolites and BPA were associated with metabolism biomarkers at age 8-14 years in patterns that varied by sex, pubertal status, and exposure timing. For example, in utero monoethyl phthalate was associated with lower insulin secretion among pubertal boys (P = .02) and higher leptin among girls (P = .04). In utero di-2-ethylhexyl phthlate was associated with higher IGF-1 among pubertal girls; peripubertal di-2-ethylhexyl phthlate was associated with higher IGF-1, insulin secretion, and resistance among prepubertal girls. In contrast, peripubertal dibutyl phthalate, monobenzyl phthalate, and mono-3-carboxypropyl phthalate were associated with lower IGF-1 among pubertal boys. Peripubertal BPA was associated with higher leptin in boys (P = .01).Considering the long-term health effects related to metabolic syndrome, additional research on exposure and metabolic outcomes across developmental periods and early adulthood is needed.

PubMed ID: 26529628 Exiting the NIEHS site

MeSH Terms: Adolescent; Adult; Benzhydryl Compounds/toxicity*; Biomarkers/blood; Blood Glucose/analysis; Blood Glucose/metabolism; Cohort Studies; Diethylhexyl Phthalate/toxicity*; Diethylhexyl Phthalate/urine; Endocrine Disruptors/toxicity*; Energy Metabolism/drug effects; Environmental Exposure/adverse effects; Female; Homeostasis; Humans; Infant, Newborn; Insulin Resistance; Leptin/blood; Longitudinal Studies; Male; Mexico/epidemiology; Middle Aged; Phenols/toxicity*; Pregnancy; Puberty/metabolism*; Sex Factors; Young Adult

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