Title: Crawling with Virus: Translational Insights from a Neonatal Mouse Model on the Pathogenesis of Respiratory Syncytial Virus in Infants.
Authors: You, Dahui; Saravia, Jordy; Siefker, David; Shrestha, Bishwas; Cormier, Stephania A
Published In J Virol, (2016 01 01)
Abstract: The infant immune response to respiratory syncytial virus (RSV) remains incompletely understood. Here we review the use of a neonatal mouse model of RSV infection to mimic severe infection in human infants. We describe numerous age-specific responses, organized by cell type, observed in RSV-infected neonatal mice and draw comparisons (when possible) to human infants.
PubMed ID: 26446604
MeSH Terms: Animals; Animals, Newborn; Disease Models, Animal*; Host-Pathogen Interactions*; Humans; Mice; Respiratory Syncytial Virus Infections/pathology*; Respiratory Syncytial Virus Infections/virology*; Respiratory Syncytial Viruses/physiology*