Title: Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium.

Authors: Huang, Ruyi; Wei, Yongyue; Hung, Rayjean J; Liu, Geoffrey; Su, Li; Zhang, Ruyang; Zong, Xuchen; Zhang, Zuo-Feng; Morgenstern, Hal; Brüske, Irene; Heinrich, Joachim; Hong, Yun-Chul; Kim, Jin Hee; Cote, Michele; Wenzlaff, Angela; Schwartz, Ann G; Stucker, Isabelle; Mclaughlin, John; Marcus, Michael W; Davies, Michael P A; Liloglou, Triantafillos; Field, John K; Matsuo, Keitaro; Barnett, Matt; Thornquist, Mark; Goodman, Gary; Wang, Yi; Chen, Size; Yang, Ping; Duell, Eric J; Andrew, Angeline S; Lazarus, Philip; Muscat, Joshua; Woll, Penella; Horsman, Janet; Teare, M Dawn; Flugelman, Anath; Rennert, Gad; Zhang, Yan; Brenner, Hermann; Stegmaier, Christa; van der Heijden, Erik H F M; Aben, Katja; Kiemeney, Lambertus; Barros-Dios, Juan; Pérez-Ríos, Monica; Ruano-Ravina, Alberto; Caporaso, Neil E; Bertazzi, Pier Alberto; Landi, Maria Teresa; Dai, Juncheng; Hongbing Shen, Hongbing; Fernandez-Tardon, Guillermo; Rodriguez-Suarez, Marta; Tardon, Adonina; Christiani, David C

Published In EBioMedicine, (2015 Nov)

Abstract: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention.We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD.Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%quit_for_5-9 years to 89%quit_for_≥ 20 years declined SCLC risk vs. subjects who had quit smoking < 5 years. Compared with non-COPD subjects, smoking behaviors showed a significantly higher effect on SCLC risk among COPD subjects, and further, COPD patients showed a 1.86-fold higher risk of SCLC. Furthermore, smoking behaviors on SCLC risk were significantly mediated through COPD which accounted for 0.70% to 7.55% of total effects.This is the largest pooling study that provides improved understanding of smoking on SCLC, and further demonstrates a causal pathway through COPD that warrants further experimental study.

PubMed ID: 26870794

MeSH Terms: No MeSH terms associated with this publication