Title: The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits.
Authors: Lusis, Aldons J; Seldin, Marcus M; Allayee, Hooman; Bennett, Brian J; Civelek, Mete; Davis, Richard C; Eskin, Eleazar; Farber, Charles R; Hui, Simon; Mehrabian, Margarete; Norheim, Frode; Pan, Calvin; Parks, Brian; Rau, Christoph D; Smith, Desmond J; Vallim, Thomas; Wang, Yibin; Wang, Jessica
Published In J Lipid Res, (2016 06)
Abstract: The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. While not nearly as powerful for mapping genetic loci contributing to the traits as human genome-wide association studies, it has some important advantages. First, environmental factors can be controlled. Second, relevant tissues are accessible for global molecular phenotyping. Finally, because inbred strains are renewable, results from separate studies can be integrated. Thus far, the HMDP has been studied for traits relevant to obesity, diabetes, atherosclerosis, osteoporosis, heart failure, immune regulation, fatty liver disease, and host-gut microbiota interactions. High-throughput technologies have been used to examine the genomes, epigenomes, transcriptomes, proteomes, metabolomes, and microbiomes of the mice under various environmental conditions. All of the published data are available and can be readily used to formulate hypotheses about genes, pathways and interactions.
PubMed ID: 27099397
MeSH Terms: Animals; Atherosclerosis/genetics; Cardiovascular Diseases/genetics*; Cardiovascular Diseases/pathology; Disease Models, Animal*; Genome-Wide Association Study; Heart Failure/genetics; Humans; Hybridization, Genetic; Insulin Resistance/genetics; Metabolic Diseases/genetics*; Metabolic Diseases/pathology; Mice; Microbiota/genetics; Obesity/genetics; Osteoporosis/genetics; Quantitative Trait Loci/genetics; Transcriptome/genetics*