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Publication Detail

Title: Deep brain stimulation and climbing fiber synaptic pathology in essential tremor.

Authors: Kuo, Sheng-Han; Lin, Chi-Ying; Wang, Jie; Liou, Jyun-You; Pan, Ming-Kai; Louis, Ravi J; Wu, Wei-Pu; Gutierrez, Jesus; Louis, Elan D; Faust, Phyllis L

Published In Ann Neurol, (2016 Sep)

Abstract: Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461-465.

PubMed ID: 27422481 Exiting the NIEHS site

MeSH Terms: Aged; Aged, 80 and over; Cerebellar Diseases/pathology*; Deep Brain Stimulation*; Essential Tremor/physiopathology*; Essential Tremor/therapy*; Female; Humans; Male; Nerve Fibers/pathology*; Severity of Illness Index; Synapses/pathology*

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