Title: New mechanisms of bacterial arsenic resistance.
Authors: Yang, Hung-Chi; Rosen, Barry P
Published In Biomed J, (2016 Feb)
Abstract: Arsenic is the most pervasive environmental substance and is classified by the International Agency for Research on Cancer as a Group 1 human carcinogen. Nearly every organism has resistance pathways for inorganic arsenic, and in bacteria, their genes are found in arsenic resistance (ars) operons. Recently, a parallel pathway for organic arsenicals has been identified. The ars genes responsible for the organoarsenical detoxification includes arsM, which encodes an As(III) S-adenosylmethionine methyltransferase, arsI, which encodes a C-As bond lyase, and arsH, which encodes a methylarsenite oxidase. The identification and properties of arsM, arsI and arsH are described in this review.
PubMed ID: 27105594
MeSH Terms: Animals; Arsenic/isolation & purification; Arsenic/metabolism*; Arsenicals/metabolism*; Bacteria*/isolation & purification; Biomarkers, Tumor/analysis*; Humans; Methyltransferases/metabolism*