Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Publication Detail

Title: Development of a microphysiological model of human kidney proximal tubule function.

Authors: Weber, Elijah J; Chapron, Alenka; Chapron, Brian D; Voellinger, Jenna L; Lidberg, Kevin A; Yeung, Catherine K; Wang, Zhican; Yamaura, Yoshiyuki; Hailey, Dale W; Neumann, Thomas; Shen, Danny D; Thummel, Kenneth E; Muczynski, Kimberly A; Himmelfarb, Jonathan; Kelly, Edward J

Published In Kidney Int, (2016 Sep)

Abstract: The kidney proximal tubule is the primary site in the nephron for excretion of waste products through a combination of active uptake and secretory processes and is also a primary target of drug-induced nephrotoxicity. Here, we describe the development and functional characterization of a 3-dimensional flow-directed human kidney proximal tubule microphysiological system. The system replicates the polarity of the proximal tubule, expresses appropriate marker proteins, exhibits biochemical and synthetic activities, as well as secretory and reabsorptive processes associated with proximal tubule function in vivo. This microphysiological system can serve as an ideal platform for ex vivo modeling of renal drug clearance and drug-induced nephrotoxicity. Additionally, this novel system can be used for preclinical screening of new chemical compounds prior to initiating human clinical trials.

PubMed ID: 27521113 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

Back
to Top