Title: The relationship of CD5+ B lymphocytes to macrophages: insights from normal biphenotypic B/macrophage cells.

Authors: Borrello, M A; Palis, J; Phipps, R P

Published In Int Rev Immunol, (2001 Feb)

Abstract: For decades, numerous investigators have reported derivation of macrophage-like cells from CD5(+) pre-B cell lymphomas. Recently, it has become clear that biphenotypic CD5(+) B/macrophage cells are not a spurious result of malignancy. Indeed, the existence of normal biphenotypic cells with CD5(+) B lymphocyte and macrophage characteristics has been demonstrated in the mouse. This review considers normal B/macrophage cell function in an evolutionary context where a primitive, flexible cell type could perform dual roles in adaptive and innate immunity.

PubMed ID: 11342302

MeSH Terms: Animals; B-Lymphocyte Subsets/cytology*; CD5 Antigens/analysis*; Cell Differentiation/drug effects; Cell Lineage; Clone Cells; Gene Rearrangement, B-Lymphocyte; Genes, ras; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology; Hematopoietic Stem Cells/cytology; Humans; Immunity, Innate; Immunophenotyping; Liver/cytology; Liver/embryology; Macrophage Colony-Stimulating Factor/pharmacology; Macrophages/cytology*; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplastic Stem Cells/cytology; Phagocytosis; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology; Tumor Cells, Cultured