Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Your Environment. Your Health.

Publication Detail

Title: Manganese Exposure and Cognition Across the Lifespan: Contemporary Review and Argument for Biphasic Dose-Response Health Effects.

Authors: Vollet, Kaitlin; Haynes, Erin N; Dietrich, Kim N

Published In Curr Environ Health Rep, (2016 12)

Abstract: Manganese (Mn) is both an essential micronutrient and potential neurotoxicant. This dual role underlies a growing body of literature demonstrating that Mn exhibits a biphasic dose-response relationship with neurocognitive outcomes. We reviewed recent epidemiologic studies from 2007 to 2016 that investigated the relationship between Mn exposure and cognitive outcomes across the lifespan: early life, school-aged children, and adulthood. In total, 27 research articles were included in this review: 12 pediatric and 15 adult studies (10 occupational and five environmental exposures). The majority of these studies provided evidence of the negative effects of Mn exposure on cognition. The pediatric literature provides evidence that both high and low levels of Mn are negatively associated with intellectual development. Future Mn research should include examination of non-linear relationships and multiple neurotoxicants across the lifespan and particularly during critical developmental windows.

PubMed ID: 27722879 Exiting the NIEHS site

MeSH Terms: Aging/physiology*; Cognition/drug effects*; Dose-Response Relationship, Drug*; Environmental Exposure/adverse effects*; Environmental Pollutants/adverse effects; Epidemiologic Studies; Humans; Manganese Poisoning; Manganese/blood; Manganese/toxicity*; Neuropsychological Tests; Occupational Exposure/adverse effects; Pediatrics

to Top