Title: Mechanisms and Modifiers of Methylmercury-Induced Neurotoxicity.
Authors: Fretham, Stephanie Jb; Caito, Samuel; Martinez-Finley, Ebany J; Aschner, Michael
Published In Toxicol Res (Camb), (2012 Jul 01)
Abstract: The neurotoxic consequences of methylmercury (MeHg) exposure have long been known, however a complete understanding of the mechanisms underlying this toxicity is elusive. Recent epidemiological and experimental studies have provided many mechanistic insights, particularly into the contribution of genetic and environmental factors that interact with MeHg to modify toxicity. This review will outline cellular processes directly and indirectly affected by MeHg, including oxidative stress, cellular signaling and gene expression, and discuss genetic, environmental and nutritional factors capable of modifying MeHg toxicity.
PubMed ID: 27795823
MeSH Terms: No MeSH terms associated with this publication