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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: Effects of lipids and antioxidants on PCB-mediated dysfunction of vascular endothelial cells (EC).

Authors: Hennig, B; Slim, R; Toborek, M; Malecki, A; Robertson, L W

Published In Cent Eur J Public Health, (2000 Jul)

Abstract: Our findings suggest that exposure to specific environmental contaminants can trigger diseases of the vasculature, e.g., cardiovascular disease. In addition, high-fat diets may potentiate and diets high in antioxidant nutrients may protect against PCB-mediated endothelial cell dysfunction. Our data give an insight into the potential use of vitamin E and related antioxidants to limit PCB-mediated cell injury. These studies are significant for providing new insights into potential nutrition interventions in diseases that can be induced by the toxicity of PCBs and other halogenated compounds.

PubMed ID: 10943440 Exiting the NIEHS site

MeSH Terms: Animals; Antioxidants/pharmacology*; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects*; Fatty Acids/pharmacology*; Polychlorinated Biphenyls/antagonists & inhibitors; Polychlorinated Biphenyls/toxicity*; Swine

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