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Publication Detail

Title: Going global by adapting local: A review of recent human adaptation.

Authors: Fan, Shaohua; Hansen, Matthew E B; Lo, Yancy; Tishkoff, Sarah A

Published In Science, (2016 10 07)

Abstract: The spread of modern humans across the globe has led to genetic adaptations to diverse local environments. Recent developments in genomic technologies, statistical analyses, and expanded sampled populations have led to improved identification and fine-mapping of genetic variants associated with adaptations to regional living conditions and dietary practices. Ongoing efforts in sequencing genomes of indigenous populations, accompanied by the growing availability of "-omics" and ancient DNA data, promises a new era in our understanding of recent human evolution and the origins of variable traits and disease risks.

PubMed ID: 27846491 Exiting the NIEHS site

MeSH Terms: Acclimatization/genetics; Adaptation, Physiological/genetics*; Altitude; Dairy Products; Environment; Gene-Environment Interaction*; Humans; Radiation Exposure; Rainforest; Selection, Genetic; Tropical Climate

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