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National Institute of Environmental Health Sciences

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Publication Detail

Title: High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source.

Authors: Barrick, Jessica; Doblas, Ana; Gardner, Michael R; Sears, Patrick R; Ostrowski, Lawrence E; Oldenburg, Amy L

Published In Opt Lett, (2016 Dec 15)

Abstract: The three most important metrics in optical coherence tomography (OCT) are resolution, speed, and sensitivity. Because there is a complex interplay between these metrics, no previous work has obtained the best performance in all three metrics simultaneously. We demonstrate that a high-power supercontinuum source, in combination with parallel spectral-domain OCT, achieves an unparalleled combination of resolution, speed, and sensitivity. This system captures cross-sectional images spanning 4  mm×0.5  mm at 1,024,000 lines/s with 2×14  μm resolution (axial×transverse) at a sensitivity of 113 dB. Imaging using the proposed system is demonstrated on highly differentiated human bronchial epithelial cells to capture and spatially localize ciliary dynamics.

PubMed ID: 27973473 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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