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Publication Detail

Title: Recommendations for quantitative analysis of small molecules by matrix-assisted laser desorption ionization mass spectrometry.

Authors: Wang, Poguang; Giese, Roger W

Published In J Chromatogr A, (2017 Feb 24)

Abstract: Matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) has been used for quantitative analysis of small molecules for many years. It is usually preceded by an LC separation step when complex samples are tested. With the development several years ago of "modern MALDI" (automation, high repetition laser, high resolution peaks), the ease of use and performance of MALDI as a quantitative technique greatly increased. This review focuses on practical aspects of modern MALDI for quantitation of small molecules conducted in an ordinary way (no special reagents, devices or techniques for the spotting step of MALDI), and includes our ordinary, preferred methods The review is organized as 18 recommendations with accompanying explanations, criticisms and exceptions.

PubMed ID: 28118972 Exiting the NIEHS site

MeSH Terms: No MeSH terms associated with this publication

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