Skip Navigation

Publication Detail

Title: Decreased maternal behavior and anxiety in ephrin-A5-/- mice.

Authors: Sheleg, M; Yu, Q; Go, C; Wagner, G C; Kusnecov, A W; Zhou, R

Published In Genes Brain Behav, (2017 Feb)

Abstract: During development of the nervous system, molecular signals mediating cell-cell interactions play critical roles in the guidance of axonal growth and establishment of synaptic functions. The Eph family of tyrosine kinase receptors and their ephrin ligands has been shown to mediate neuronal interactions in the development of topographic axon projection maps in several brain regions, and the loss of Eph activities result in defects in select axonal pathways. However, effects of deficiencies of the Eph signals on animal behavior have not been well documented. In this study, we showed that inactivation of a ligand of the Eph receptors, ephrin-A5, resulted in defects in maternal behavior and alterations in anxiety. Female ephrin-A5 -/- mice show significant defects in nest building and pup retrieval. In addition, lower levels of anxiety were observed in both male and female null mice. These changes were not due to deficiencies in estradiol, progesterone or corticosterone levels. Our observations suggest that ephrin-A5 plays a key role in the development and/or function of neural pathways mediating mouse maternal care and anxiety.

PubMed ID: 27535576 Exiting the NIEHS site

MeSH Terms: Animals; Anxiety/genetics; Anxiety/metabolism; Axons/metabolism; Ephrin-A5/deficiency*; Ephrin-A5/genetics*; Ephrin-A5/metabolism; Female; Male; Maternal Behavior/physiology*; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Pathways/metabolism; Neurons/metabolism; Pregnancy; Receptor Protein-Tyrosine Kinases/genetics; Receptor Protein-Tyrosine Kinases/metabolism; Signal Transduction/drug effects

Back
to Top