Title: Autoimmunity, Autoantibodies, and Autism Spectrum Disorder.
Authors: Edmiston, Elizabeth; Ashwood, Paul; Van de Water, Judy
Published In Biol Psychiatry, (2017 03 01)
Abstract: Auism spectrum disorder (ASD) now affects one in 68 births in the United States and is the fastest growing neurodevelopmental disability worldwide. Alarmingly, for the majority of cases, the causes of ASD are largely unknown, but it is becoming increasingly accepted that ASD is no longer defined simply as a behavioral disorder, but rather as a highly complex and heterogeneous biological disorder. Although research has focused on the identification of genetic abnormalities, emerging studies increasingly suggest that immune dysfunction is a viable risk factor contributing to the neurodevelopmental deficits observed in ASD. This review summarizes the investigations implicating autoimmunity and autoantibodies in ASD.
PubMed ID: 28340985
MeSH Terms: Animals; Autism Spectrum Disorder/genetics; Autism Spectrum Disorder/immunology*; Autoantibodies/immunology*; Autoimmunity*; Brain/immunology; Disease Models, Animal; Female; Humans; Macaca mulatta; Maternal-Fetal Exchange; Pregnancy; Risk Factors