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Publication Detail

Title: Regional Variation in Skeletal Muscle and Adipose Tissue FDG Uptake Using PET/CT and Their Relation to BMI.

Authors: Goncalves, Marcus D; Green-McKenzie, Judith; Alavi, Abass; Torigian, Drew A

Published In Acad Radiol, (2017 10)

Abstract: Skeletal muscle metabolism is a primary contributor to whole-body energy expenditure. Currently, methods to measure changes in skeletal muscle metabolism in vivo are limited. Our objectives were to characterize the regional variation in skeletal muscle and adipose tissue (AT) FDG uptake as a surrogate for glycolytic metabolism using 18F-2-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in healthy men and to correlate these findings to body mass index (BMI).Eighteen healthy men were enrolled and underwent FDG-PET/CT. The mean standardized uptake value of 14 skeletal muscles and two AT regions was measured and linear regression analysis was performed to identify metabolic predictors of BMI.FDG-PET/CT reliably detected changes in skeletal muscle and AT depot metabolic activity based on location. The most metabolically active muscles were those used for posture and breathing, which have the highest percentage of reported type I muscle myofiber content. Visceral AT tended to have a higher FDG uptake than subcutaneous AT. The mean standardized uptake value of VAT, pectoralis major, and gluteus maximus muscles accounted for 64% of the variance in BMI.FDG-PET/CT can be used to quantify the regional variation in glucose metabolism of multiple skeletal muscle groups and AT depots.

PubMed ID: 28551398 Exiting the NIEHS site

MeSH Terms: Adipose Tissue/diagnostic imaging*; Adipose Tissue/metabolism*; Adult; Body Mass Index; Energy Metabolism; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Muscle, Skeletal/diagnostic imaging*; Muscle, Skeletal/metabolism*; Pilot Projects; Positron Emission Tomography Computed Tomography*; Prospective Studies; Radiopharmaceuticals; Subcutaneous Fat/diagnostic imaging; Subcutaneous Fat/metabolism

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