Title: Type two innate lymphoid cells: the Janus cells in health and disease.
Authors: Maazi, Hadi; Akbari, Omid
Published In Immunol Rev, (2017 07)
Abstract: Innate lymphoid cells are functionally diverse subsets of immune cells including the conventional natural killer cells, lymphoid tissue inducers, type 1, 2, and 3 with significant roles in immunity and pathogenesis of inflammatory diseases. Type 2 innate lymphoid cells (ILC2s) resemble type 2 helper (Th2) cells in cytokine production and contribute to anti-helminth immunity, maintaining mucosal tissue integrity, and adipose tissue browning. ILC2s play important roles in the pathogenesis of allergic diseases and asthma. Studying the pathways of activation and regulation of ILC2s are currently a priority for giving a better understanding of pathogenesis of diseases with immunological roots. Recently, our laboratory and others have shown several pathways of regulation of ILC2s by co-stimulatory molecules such as ICOS, regulatory T cells and by compounds such as nicotine. In this review, we summarize the current understanding of the mechanisms of activation and regulation of ILC2s and the role of these cells in health and disease.
PubMed ID: 28658553
MeSH Terms: Animals; Biomarkers; Cell Plasticity/genetics; Cell Plasticity/immunology; Cytokines/metabolism; Disease Susceptibility; Gene Expression Regulation; Humans; Immunity; Immunity, Innate*; Immunologic Memory; Immunomodulation; Lymphocyte Activation/genetics; Lymphocyte Activation/immunology; Lymphocyte Subsets/immunology*; Lymphocyte Subsets/metabolism*; Phenotype; Th2 Cells/immunology*; Th2 Cells/metabolism*