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Title: Stage IV colorectal cancer primary site and patterns of distant metastasis.

Authors: Robinson, Jamaica R; Newcomb, Polly A; Hardikar, Sheetal; Cohen, Stacey A; Phipps, Amanda I

Published In Cancer Epidemiol, (2017 Jun)

Abstract: Although colorectal cancer (CRC) usually metastasizes to the liver and/or lungs, factors influencing the anatomic pattern of metastases remain poorly understood.We assessed the relationship between primary CRC site and pattern of synchronous metastasis among 1202 individuals diagnosed with incident metastatic CRC between 2010 and 2014 and identified through the Seattle-Puget Sound Surveillance, Epidemiology, and End Results (SEER) registry. Polytomous logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between primary tumor site and synchronous metastatic pattern.Compared to patients with proximal colon primaries, patients with rectal primaries were more likely to present with lungs-only or liver and lungs metastases versus liver-only metastases (ORlungs-onlyvs.liver-only: 2.39, 95% CI: 1.35-4.24, ORliver+lungsvs.liver-only: 2.20, 95% CI: 1.46-3.32).These findings suggest that patients with rectal primaries are more likely than patients with colon primaries to present with synchronous lung metastases.

PubMed ID: 28437692 Exiting the NIEHS site

MeSH Terms: Aged; Colorectal Neoplasms/epidemiology*; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging

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